Summary information and primary citation
- PDB-id
-
205d;
DSSR-derived features in text and
JSON formats
- Class
- RNA
- Method
- X-ray (2.64 Å)
- Summary
- Structure of an RNA double helix including
uracil-uracil base pairs in an internal loop
- Reference
-
Baeyens KJ, De Bondt HL, Holbrook SR (1995): "Structure
of an RNA double helix including uracil-uracil base pairs
in an internal loop." Nat.Struct.Biol.,
2, 56-62. doi: 10.1038/nsb0195-56.
- Abstract
- The crystal structure of the RNA dodecamer
5'-GGACUUUGGUCC-3' has been determined from X-ray
diffraction data to 2.6 A resolution. This oligomer forms
an asymmetric double helix in the crystal. Four consecutive
non-Watson-Crick base-pairs are formed in the middle of the
duplex including the first intrahelical U-U (or T-T) pairs
observed in an oligonucleotide crystal structure. Two
different conformations of U-U pairs are observed in the
context of the surrounding sequence. One of these pairs is
highly twisted, allowing a bound water to bridge across
strands in the major groove. The crystal packing
illustrates a new form of RNA helix-helix interaction.
